The Markx lab is currently carrying out a number. They also provide insight into the link between micro-RNA dysregulation and genetic liability to schizophrenia and cognitive dysfunction. Markx graduated from the Universiteit Van Amsterdam Faculteit Der Geneeskunde in 2004. After graduation, he joined the Columbia Psychiatry faculty and was named the Director of Precision Psychiatry. Our findings inform the cortical synaptic and neuronal mechanisms of working memory impairment in the context of psychiatric disorders. Sander Markx is a provider established in New York, New York and his medical specialization is Psychiatric Hospital. He graduated from UNIVERSITY OF ALASKA / ANCHORAGE CAMPUS in 2004. Reduction in Dgcr8 levels appears to be a major driver of altered short-term synaptic plasticity in prefrontal cortex and working memory but not of long-term plasticity and cytoarchitecture. Sander Markx, MD is a Psychiatry Specialist in New York, NY and has over 18 years of experience in the medical field. We confirmed the pronounced DiGeorge critical region 8 ( Dgcr8)-dependent deficits in primary micro-RNA processing and identified additional changes in gene expression and RNA splicing that may underlie the effects of this mutation. Apart from previously reported reduction in dendritic complexity of layer 5 pyramidal neurons, altered synaptic plasticity occurs in the context of relatively circumscribed and often subtle cytoarchitectural changes in neuronal density and inhibitory neuron numbers. Guided by cognitive deficits, we demonstrated that mutant mice display robust deficits in high-frequency synaptic transmission and short-term plasticity (synaptic depression and potentiation), as well as alterations in long-term plasticity and dendritic spine stability. We used a mouse model of the schizophrenia-predisposing 22q11.2 microdeletion to evaluate how this genetic lesion affects cortical neural circuits at the synaptic, cellular, and molecular levels.
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